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| POSE (Protein Optimization
Steering Environment) is a graphical, interactive environment for the
design, modeling, and optimization of protein structures. POSE is a
successor of ProteinShop [1,2], a program that facilitates the solution
of the protein prediction problem through a combination of interactive
features and visualization capabilities. Like ProteinShop, POSE allows
users to manipulate protein structures with pinpoint control guided by
their biological and experimental instinct. On the other hand, POSE's
extended capabilities support other applications like molecular
docking. POSE was designed to improve and expand the interactive
computing graphics capabilities of ProteinShop. POSE was motivated by
our conviction that only such level of interaction will help scientists
learn about the complex biological systems they try to simulate and help them find solutions. Among its main features we would like to highlight: 1) automatic creation of 3-D structures from sequence, 2) manual alignment of beta strands to form beta-sheets, 3) easy coupling with user-provided energy and scoring functions, 4) real-time hydrogen-bond and atom-collision detection, and 5) local minimizations. |
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